[Remote] Clinical Genomics Scientist, Oncology

Note: The job is a remote job and is open to candidates in USA. BillionToOne is a next-generation molecular diagnostics company focused on transforming healthcare through innovative diagnostic solutions. They are seeking a Clinical Genomics Scientist in Oncology to drive somatic mutation variant interpretation and reporting, contributing to the development of clinical reporting policies and collaborating with various teams to enhance patient care.

Responsibilities

• Somatic variant interpretation and data review: Perform somatic-based variant interpretation, diving into the literature and databases to classify variants and match treatments for reporting, performing verification as required with BAM file analysis
• Clinical report drafting: Carefully draft reports for each requisition primarily using in-house reporting API, working closely with the engineering and QA teams on reporting, and the laboratory directors on report language
• Somatic mutation interpretation and reporting policy development: Work closely with lab directors, R&D, medical, and other related functions to develop and modify the somatic interpretation SOPs in accordance with ACMG/AMP guidelines, and the latest published literature
• Content curation: Contribute to curation of gene-level content such as domain and critical residue curation.Molecular tumor board: Serve as a subject matter expert in consulting with the medical science liaison team, and presenting in molecular tumor boards to facilitate knowledge sharing
• Contribute to oncology R&D: Work closely with the R&D team to help with somatic oncology based projects, providing expertise on variant interpretation, biological pathways/mechanisms, and other gene/variant-level reviews and analyses

Skills

• Ph.D. in Human Genetics, M.S. in Genetic Counseling, or related field
• 2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines in a clinical setting (alternatively, 1+ years of germline variant interpretation and 1+ years of somatic variant interpretation experience)
• Hands-on experience working with human mutation databases (COSMIC, ClinVar, OncoKB), functional annotation sources (dbSNP), and genome browsers (UCSC)
• Familiarity with IGV and BAM file analysis and data-minded willingness to learn to use basic bioinformatics tools, with technically minded insights
• Knowledge of cancer somatic mutation and signaling pathways (e.g., which mutations have FDA approved drugs, Phase II/III clinical trials, which mutations are considered “hot targets” for drug development, etc.)
• Exceptional attention to detail to follow highly detailed SOPs and strong organizational skills to track and manage clinical reporting and product improvement projects
• Excellent communication skills and ability to work collaboratively with cross-functional teams
• Operationally-defined flexible schedule, including weekends, as dictated by clinical reporting needs

Benefits

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Generous equity options offering
• Corporate bonus program
• Industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.)

Company Overview

• BillionToOne is a precision diagnostics company that focuses on genetic testing for disease detection. It was founded in 2016, and is headquartered in Menlo Park, California, USA, with a workforce of 501-1000 employees. Its website is https://www.billiontoone.com.

Company H1B Sponsorship

• BillionToOne has a track record of offering H1B sponsorships, with 7 in 2025, 6 in 2024, 3 in 2023, 2 in 2022, 1 in 2021, 2 in 2020. Please note that this does not guarantee sponsorship for this specific role.

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